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LTK Antibody (PACO55602)

SKU:
PACO55602
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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LTK Antibody (PACO55602)

The LTK Antibody (PAC056602) is a highly specific and sensitive tool for researchers studying the LTK protein, a receptor tyrosine kinase that has been implicated in a variety of cellular processes including cell growth, differentiation, and migration. This polyclonal antibody, derived from rabbit serum, has been validated for use in applications such as Western blot and immunofluorescence.With its high reactivity to human samples, the LTK Antibody enables researchers to accurately detect and analyze the LTK protein in various cell types, making it an indispensable tool for investigations in cell signaling, cancer biology, and developmental biology.

By targeting the LTK protein, researchers can gain valuable insights into the role of this receptor kinase in normal cellular function and disease pathology.The LTK Antibody from AssayGenie offers researchers a reliable and effective tool for studying the LTK protein and its involvement in key cellular processes. Whether investigating the mechanisms of cancer progression or exploring the potential therapeutic applications of targeting LTK, this antibody provides a valuable resource for advancing research in molecular biology and oncology.

Antibody Name:LTK Antibody (PACO55602)
Antibody SKU:PACO55602
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Leukocyte tyrosine kinase receptor protein (20-175AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescence staining of HepG2 cells with PACO55602 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
Synonyms:Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1), LTK, TYK1
UniProt Protein Function:LTK: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Homodimer when bound to ligand (Probable). Part a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Expressed in non-hematopoietic cell lines and T- and B-cell lines. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Alk family

Chromosomal Location of Human Ortholog: 15q15.1-q21.1

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function:protein kinase activity; protein-tyrosine kinase activity

Biological Process: cell proliferation; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; protein amino acid phosphorylation; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Code:P29376
NCBI GenInfo Identifier:143811416
NCBI Gene ID:4058
NCBI Accession:P29376.3
UniProt Secondary Accession:P29376,A6NNJ8, B4DL89, E9PFX4,
UniProt Related Accession:P29376
Molecular Weight:78,714 Da
NCBI Full Name:Leukocyte tyrosine kinase receptor
NCBI Synonym Full Names:leukocyte receptor tyrosine kinase
NCBI Official Symbol:LTK  
NCBI Official Synonym Symbols:TYK1  
NCBI Protein Information:leukocyte tyrosine kinase receptor
UniProt Protein Name:Leukocyte tyrosine kinase receptor
UniProt Synonym Protein Names:Protein tyrosine kinase 1
Protein Family:Leukocyte tyrosine kinase receptor
UniProt Gene Name:LTK  
UniProt Entry Name:LTK_HUMAN
AntibodiesELISA Kits
LTK Antibody (PACO04255)Human LTK / Leukocyte Receptor Tyrosine Kinase ELISA Kit
Human Leukocyte tyrosine kinase receptor (LTK) ELISA Kit
LTK Colorimetric Cell-Based ELISA
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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