The LTK Antibody (PAC021766) provided by AssayGenie is a high-quality polyclonal antibody designed for research involving the leukocyte receptor tyrosine kinase (LTK). This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications.LTK is a cell surface receptor tyrosine kinase that plays a critical role in various cellular processes, including cell growth, differentiation, and survival. Dysregulation of LTK has been implicated in various diseases, making it a valuable target for research in cancer, inflammation, and other pathological conditions.By binding to the LTK protein, this antibody enables accurate detection and analysis of LTK expression in different cell types, making it an ideal tool for studies in cancer biology, signaling pathways, and targeted therapies.
Understanding the role of LTK in disease pathogenesis is essential for the development of novel therapeutic strategies that target this receptor.In summary, the LTK Antibody (PAC021766) from AssayGenie is a reliable tool for researchers studying LTK function and its implications in disease mechanisms. Its specificity and sensitivity make it a valuable asset for immunology, oncology, and other fields of biomedical research.
Antibody Name:
LTK Antibody (PACO21766)
Antibody SKU:
PACO21766
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human LTK.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using LTK antibody.
Background:
Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Krolewski J.J., EMBO J. 10:2911-2919(1991).
LTK: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Homodimer when bound to ligand (Probable). Part a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Expressed in non-hematopoietic cell lines and T- and B-cell lines. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Alk family
Chromosomal Location of Human Ortholog: 15q15.1-q21.1
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Biological Process: cell proliferation; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; protein amino acid phosphorylation; signal transduction
NCBI Summary:
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
