LTK Antibody (PACO04255)
- SKU:
- PACO04255
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
LTK Antibody (PACO04255)
The LTK Antibody (PAC004255) is a valuable tool for researchers studying the LTK (leukocyte receptor tyrosine kinase) protein, a receptor that is involved in cell signaling and proliferation. This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications.LTK is known to play a role in multiple cellular processes, including cell growth, differentiation, and survival. Dysregulation of LTK expression or activity has been implicated in various diseases, including cancer.
Therefore, the LTK Antibody is a crucial tool for studying the function and regulation of LTK in both normal and disease states.Researchers in the fields of cell biology, cancer biology, and drug development can benefit from using the LTK Antibody to investigate the role of LTK in cellular signaling pathways and potential therapeutic targets. Its specificity and reliability make it an essential component of any study involving LTK protein analysis.
| Antibody Name: | LTK Antibody |
| Antibody SKU: | PACO04255 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human LTK. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | LTK; TYK1; Leukocyte tyrosine kinase receptor; Protein tyrosine kinase 1 |
| UniProt Protein Function: | LTK: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. Homodimer when bound to ligand (Probable). Part a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Expressed in non-hematopoietic cell lines and T- and B-cell lines. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Alk family Chromosomal Location of Human Ortholog: 15q15.1-q21.1 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:protein kinase activity; protein-tyrosine kinase activity Biological Process: cell proliferation; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; protein amino acid phosphorylation; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P29376 |
| NCBI GenInfo Identifier: | 143811416 |
| NCBI Gene ID: | 4058 |
| NCBI Accession: | P29376.3 |
| UniProt Secondary Accession: | P29376,A6NNJ8, B4DL89, E9PFX4, |
| UniProt Related Accession: | P29376 |
| Molecular Weight: | 78,714 Da |
| NCBI Full Name: | Leukocyte tyrosine kinase receptor |
| NCBI Synonym Full Names: | leukocyte receptor tyrosine kinase |
| NCBI Official Symbol: | LTKÂ Â |
| NCBI Official Synonym Symbols: | TYK1Â Â |
| NCBI Protein Information: | leukocyte tyrosine kinase receptor |
| UniProt Protein Name: | Leukocyte tyrosine kinase receptor |
| UniProt Synonym Protein Names: | Protein tyrosine kinase 1 |
| Protein Family: | Leukocyte tyrosine kinase receptor |
| UniProt Gene Name: | LTKÂ Â |
| UniProt Entry Name: | LTK_HUMAN |
Related Products
LTK Antibody (PACO55602)
LTK Antibody (PACO21766)
LTK Colorimetric Cell-Based ELISA (CBCAB00997)
Human Phosphotyrosine LTK PharmaGenie ELISA Kit (SBRS1885)
Human LTK / Leukocyte Receptor Tyrosine Kinase ELISA Kit (HUFI01210)
Human Leukocyte tyrosine kinase receptor (LTK) ELISA Kit (HUEB1383)
Mouse Leukocyte tyrosine kinase receptor (Ltk) ELISA Kit (MOEB1155)
OSTN Antibody (PACO64881)
