LTB Antibody (PACO07384)
- SKU:
- PACO07384
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
LTB Antibody (PACO07384)
The LTB Antibody (PACO07384) is a vital tool for researchers studying the LTB protein, which is involved in various cellular processes. This polyclonal antibody, produced in rabbits, demonstrates high reactivity with human samples and has been verified for use in Western blot techniques. By binding specifically to the LTB protein, this antibody facilitates the detection and analysis of LTB in a variety of cell types, making it an excellent choice for investigations in immunology and cancer research.
LTB, also referred to as lymphotoxin beta, plays a crucial role in immune system regulation and inflammatory responses. Its involvement in immune signaling pathways and its connection to various disease states, including cancer, autoimmune disorders, and inflammatory conditions, make it a promising target for therapeutic exploration. By studying the functions of LTB, researchers can gain insights into potential treatment approaches that modulate immune responses and address disease progression.
| Antibody Name: | LTB Antibody (PACO07384) |
| Antibody SKU: | PACO07384 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:10000-1:20000, IHC-p:1:50-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide from human protein at AA range: 41-90 |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200. |
 | Immunohistochemical analysis of paraffin-embedded human-spleen, antibody was diluted at 1:200. |
 | Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200. |
| Synonyms: | Lymphotoxin-β (LT-β) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3) |
| UniProt Protein Function: | LTB: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: extracellular space; integral to membrane Molecular Function:cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: skin development; positive regulation of interleukin-12 biosynthetic process; cell-cell signaling; gene expression; immune response; signal transduction; lymph node development |
| NCBI Summary: | Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q06643 |
| NCBI GenInfo Identifier: | 4505035 |
| NCBI Gene ID: | 4050 |
| NCBI Accession: | NP_002332.1 |
| UniProt Related Accession: | Q06643 |
| Molecular Weight: | ~ 25kDa |
| NCBI Full Name: | lymphotoxin-beta isoform a |
| NCBI Synonym Full Names: | lymphotoxin beta |
| NCBI Official Symbol: | LTBÂ Â |
| NCBI Official Synonym Symbols: | p33; TNFC; TNFSF3; TNLG1CÂ Â |
| NCBI Protein Information: | lymphotoxin-beta |
| UniProt Protein Name: | Lymphotoxin-beta |
| UniProt Synonym Protein Names: | Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3 |
| UniProt Gene Name: | LTBÂ Â |
| UniProt Entry Name: | TNFC_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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