The LTA4H Polyclonal Antibody (CAB2502) is a valuable tool for researchers studying LTA4H, an enzyme involved in the production of leukotriene B4, a potent inflammatory mediator. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the LTA4H protein, researchers can accurately detect and analyze its expression in a variety of cell types.
LTA4H plays a crucial role in the inflammatory response and has been implicated in a range of diseases, including asthma, inflammatory bowel disease, and cancer. Understanding the function and regulation of LTA4H is essential for developing targeted therapies for these conditions. The LTA4H Polyclonal Antibody is a valuable tool for researchers seeking to unravel the complex role of this enzyme in health and disease.
Product Name:
LTA4H Rabbit Polyclonal Antibody
SKU:
CAB2502
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 312-611 of human LTA4H (NP_000886.1).
293T,HepG2,PC-3,SW620,BT-474,Ramos,Mouse spleen,Mouse brain,Mouse bone marrow
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm.
Calculated MW:
69kDa
Observed MW:
69kDa
The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4048
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using LTA4H Rabbit pAb (CAB2502) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.