The LSM6 Polyclonal Antibody (PAC028049) is a valuable tool for researchers studying the LSM6 protein, which is involved in RNA processing and splicing. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the LSM6 protein, this antibody allows for the detection and analysis of LSM6 in various cell types, making it an excellent choice for studies in molecular biology and gene expression.LSM6 is a key player in RNA metabolism, playing a crucial role in processing precursor messenger RNA (pre-mRNA) into mature mRNA.
Dysregulation of LSM6 has been implicated in various diseases, including cancer and genetic disorders. Understanding the function and regulation of LSM6 is essential for unraveling the complexities of gene expression and developing targeted therapies for related conditions.Overall, the LSM6 Polyclonal Antibody is a reliable tool for investigating the function and significance of LSM6 in biological processes, making it a valuable asset for researchers in the field of molecular biology and RNA biology.
Antibody Name:
LSM6 Antibody (PACO28049)
Antibody SKU:
PACO28049
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human U6 snRNA-associated Sm-like protein LSm6 protein (1-80AA)
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
Synonyms:
U6 snRNA-associated Sm-like protein LSm6, LSM6
UniProt Protein Function:
LSM6: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'- terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre- rRNAs and U3 snoRNA. Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.Protein type: Spliceosome; RNA processingChromosomal Location of Human Ortholog: 4q31.22Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; small nucleolar ribonucleoprotein complex; U4/U6 x U5 tri-snRNP complex; nucleolus; cytosolMolecular Function: protein bindingBiological Process: nuclear mRNA splicing, via spliceosome; tRNA processing; RNA splicing; gene expression; mRNA catabolic process, deadenylation-dependent decay; maturation of SSU-rRNA
UniProt Protein Details:
NCBI Summary:
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
