The LSM5 Polyclonal Antibody (PACO10303) is a valuable tool for researchers studying LSM5, a key component of the spliceosome complex involved in pre-mRNA splicing. This antibody is generated using rabbit immunization and has high specificity for human samples, making it suitable for Western blot applications. By targeting the LSM5 protein, this antibody enables precise detection and analysis of LSM5 levels in different cell types, making it ideal for studies in molecular biology and gene expression regulation.LSM5 is essential for the accurate splicing of mRNA, a crucial step in gene expression regulation. Dysregulation of LSM5 has been implicated in a variety of diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular function.
By understanding the role of LSM5 in splicing mechanisms, researchers can gain insights into disease pathways and potentially identify therapeutic targets for intervention.Overall, the LSM5 Polyclonal Antibody is a powerful tool for investigating the functions of LSM5 and its implications in various biological processes. Its versatility and specificity make it a valuable asset for researchers seeking to unravel the complexities of gene expression regulation and its impact on human health.
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae);LSM5;FLJ12710;YER146W ;
UniProt Protein Function:
LSM5: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. Belongs to the snRNP Sm proteins family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-binding; RNA processingChromosomal Location of Human Ortholog: 7p14.3Cellular Component: cytosol; nucleoplasm; nucleus; spliceosome; U4/U6 x U5 tri-snRNP complexMolecular Function: protein binding; RNA bindingBiological Process: mRNA processing; nuclear mRNA splicing, via spliceosome
UniProt Protein Details:
NCBI Summary:
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
