The LSM1 Polyclonal Antibody (CAB12732) is a valuable tool for researchers studying the LSM1 protein, a key player in RNA processing and gene regulation. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By binding specifically to the LSM1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and genetic research.LSM1 is an essential component of the mRNA degradation machinery, and its function is critical for the regulation of gene expression.
Dysregulation of LSM1 has been implicated in various diseases, including cancer and neurodegenerative disorders. By gaining insights into the role of LSM1 in RNA metabolism, researchers can uncover potential targets for therapeutic interventions and develop innovative treatments for these diseases. The LSM1 Polyclonal Antibody is a valuable resource for advancing our understanding of RNA biology and its impact on human health.
Product Name:
LSM1 Rabbit Polyclonal Antibody
SKU:
CAB12732
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-133 of human LSM1 (NP_055277.1).
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
Purification Method:
Affinity purification
Gene ID:
27257
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LSM1 Rabbit pAb (CAB12732) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
