The LRWD1 Polyclonal Antibody is a powerful tool for researchers studying LRWD1, a protein involved in epigenetic regulation and cellular processes. This antibody is raised in rabbits and is highly specific for detecting LRWD1 in human samples, making it ideal for Western blot applications. By targeting the LRWD1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, facilitating research in fields such as molecular biology and cancer biology.LRWD1, also known as Leucine-rich repeat and WD repeat-containing protein 1, is known to play a crucial role in chromatin organization and gene expression regulation.
Its involvement in epigenetic mechanisms makes it a key player in cell function and development, and dysregulation of LRWD1 has been linked to various diseases, including cancers and neurodevelopmental disorders. By studying LRWD1 with this antibody, researchers can gain valuable insights into its functions and potential therapeutic targets for disease intervention.
Product Name:
Lrwd1 Polyclonal Antibody
SKU:
CAB21399
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Lrwd1 (NP_690852.1).
Chromosome, Cytoplasm, Nucleus, centromere, centrosome, cytoskeleton, microtubule organizing center, telomere.
Calculated MW:
71kDa
Observed MW:
Refer to figures
The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
222229
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Lrwd1 Rabbit pAb (CAB21399) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
