The LRTOMT Antibody (PAC031268) is a valuable tool for researchers studying LRTOMT, a protein involved in vitamin B12 metabolism and essential for cellular health. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting LRTOMT in human samples, particularly in Western blot applications. By targeting the LRTOMT protein, researchers can study its function and expression levels in various cell types, providing insights into vitamin B12-related pathways and potential therapeutic targets.LRTOMT is a critical enzyme in the vitamin B12 pathway, responsible for converting cobalamin into the active form of the vitamin.
Dysregulation of LRTOMT activity has been linked to various health conditions, including anemia and neurological disorders. By investigating the role of LRTOMT in cellular metabolism, researchers can uncover new mechanisms for disease development and potential treatment strategies.Overall, the LRTOMT Antibody (PAC031268) offers researchers a reliable tool for studying LRTOMT function and its implications for human health. Its effectiveness in detecting LRTOMT protein expression makes it an essential component in studies related to vitamin B12 metabolism, metabolic disorders, and potential therapeutic interventions.
Antibody Name:
LRTOMT Antibody (PACO31268)
Antibody SKU:
PACO31268
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Transmembrane O-methyltransferase protein (31-264AA)
Immunofluorescent analysis of HepG2 cells using PACO31268 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
LRTOMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Defects in LRTOMT are the cause of deafness autosomal recessive type 63 (DFNB63). A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the methyltransferase superfamily. Catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.1.1.6; Membrane protein, integral; Methyltransferase; Cell development/differentiationChromosomal Location of Human Ortholog: 11q13.4Molecular Function: catechol O-methyltransferase activityBiological Process: auditory receptor cell development; catecholamine catabolic process; sensory perception of soundDisease: Deafness, Autosomal Recessive 63
UniProt Protein Details:
NCBI Summary:
This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]
