The LRTM2 Monoclonal Antibody (PAC062079) is a high-quality antibody designed for research involving LRTM2, a synaptic adhesion molecule involved in neural development and synaptic plasticity. This antibody, produced in mice, is specifically reactive with human samples and is validated for use in various applications, including immunofluorescence and immunohistochemistry.LRTM2 is a crucial player in the formation and maintenance of synapses, playing a role in synaptic transmission and plasticity. Dysregulation of LRTM2 has been linked to neurodevelopmental disorders and cognitive impairments.
Therefore, studying the function and expression of LRTM2 is essential for understanding synaptic function and cognitive processes.This antibody binds specifically to the LRTM2 protein, allowing for its detection and localization in neuronal tissues. Its high specificity and sensitivity make it an ideal tool for researchers studying synaptic function, neural development, and neurodevelopmental disorders. By targeting LRTM2, researchers can gain valuable insights into synaptic biology and potentially develop new therapeutic strategies for neurological disorders.
Western Blot. Positive WB detected in: SH-SY5Y whole cell lysate, U251 whole cell lysate, Rat brain tissue. All lanes: LRTM2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 42 kDa. Observed band size: 42 kDa.
Immunofluorescence staining of HepG2 cells with PACO62079 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO62079 diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
cytoplasm, protein kinase inhibitor activity, cytokine-mediated signaling pathway, negative regulation of JAK-STAT cascade, negative regulation of protein kinase activity.
Synonyms:
Leucine-rich repeat and transmembrane domain-containing protein 2, LRTM2
UniProt Protein Function:
LRTM2: Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.33Biological Process: axonogenesis
