The LRRN2 Polyclonal Antibody (PAC028025) is a valuable tool for researchers studying LRRN2, a protein involved in neural development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the LRRN2 protein, this antibody enables researchers to detect and analyze LRRN2 expression in various cell types, making it an ideal choice for studies in neuroscience and neurodevelopmental disorders.LRRN2, also known as Leucine-rich repeat neuronal protein 2, plays a crucial role in promoting neuronal survival and synaptic connectivity in the brain. Its importance in neural circuit formation and function suggests its potential involvement in neurological disorders and cognitive impairments.
By studying the function of LRRN2, researchers can gain insights into the mechanisms underlying brain development and potentially identify new therapeutic targets for neurodevelopmental disorders.The LRRN2 Polyclonal Antibody is a valuable tool for researchers aiming to unravel the molecular mechanisms governing neural development and function. Its high specificity and sensitivity make it a reliable choice for detecting LRRN2 expression in various experimental settings, providing valuable information for studies in neuroscience, neurobiology, and neurodevelopment.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO28025 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO28025 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
receptor activity, cell adhesion, signal transduction
Synonyms:
Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5), LRRN2, GAC1 LRRN5
UniProt Protein Function:
LRRN2: Protein type: Membrane protein, integral; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 1q32.1Cellular Component: integral to membraneMolecular Function: receptor activityBiological Process: signal transduction; cell adhesion
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
