The LRRK2 Polyclonal Antibody is a key tool for researchers studying the Leucine-rich repeat kinase 2 (LRRK2) protein, which has been linked to Parkinson's disease and other neurodegenerative disorders. This antibody, produced in rabbits, is highly sensitive and specific for detecting LRRK2 in human samples, making it valuable for research in neuroscience and neurology.LRRK2 is a multi-domain protein that plays a role in various cellular processes, including cell survival, autophagy, and inflammation. Dysregulation of LRRK2 has been implicated in the pathogenesis of Parkinson's disease, making it a promising therapeutic target.
By using the LRRK2 Polyclonal Antibody in Western blot applications, researchers can study the expression and function of LRRK2 in different cell types and tissues to gain insights into disease mechanisms and potential treatment strategies.Overall, the LRRK2 Polyclonal Antibody is a reliable tool for investigating the role of LRRK2 in neurodegenerative diseases and advancing our understanding of the molecular mechanisms underlying these conditions. Its high reactivity and specificity make it an essential reagent for researchers working in the field of neurobiology and drug discovery.
Product Name:
LRRK2 Rabbit Polyclonal Antibody
SKU:
CAB0859
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 750-910 of human LRRK2 (NP_940980.3).
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Purification Method:
Affinity purification
Gene ID:
120892
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat lung, using LRRK2 antibody (CAB0859) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
