The LRRK2 Rabbit Polyclonal Antibody (CAB17253) is an essential tool for studying LRRK2, a protein kinase involved in Parkinson's disease and other neurological disorders. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting LRRK2 in human samples, making it ideal for use in Western blot applications. By targeting the LRRK2 protein, researchers can gain valuable insights into its function and potential role in disease pathology.LRRK2, also known as leucine-rich repeat kinase 2, is a key player in regulating various cellular processes, including autophagy and inflammation. Dysregulation of LRRK2 has been linked to the development of Parkinson's disease, making it a promising therapeutic target for drug discovery efforts.
By studying the activity of LRRK2 using this antibody, researchers can advance our understanding of neurodegenerative diseases and potentially develop novel treatment strategies.Overall, the LRRK2 Rabbit Polyclonal Antibody (CAB17253) offers a reliable and effective means of investigating the role of LRRK2 in health and disease. Its high reactivity and specificity make it a valuable tool for researchers in the fields of neuroscience, neurology, and drug development.
Product Name:
LRRK2 Rabbit Polyclonal Antibody
SKU:
CAB17253
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 750-910 of human LRRK2 (NP_940980.3).
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Purification Method:
Affinity purification
Gene ID:
120892
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung, using LRRK2 Rabbit pAb (CAB17253) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
