The LRRK2 Monoclonal Antibody is a vital tool for researchers studying the LRRK2 protein, a key player in the pathology of Parkinson's disease. This antibody, produced using hybridoma technology, shows high specificity and sensitivity in detecting LRRK2 in human samples, making it ideal for use in Western blot and immunohistochemistry applications.LRRK2, a multidomain protein kinase, is involved in various cellular processes, including autophagy, inflammation, and neuronal survival.
Dysregulation of LRRK2 has been linked to the development and progression of Parkinson's disease, making it a promising target for therapeutic interventions. The LRRK2 Monoclonal Antibody enables researchers to study the expression and function of LRRK2 in different cell types and tissues, advancing our understanding of its role in neurodegeneration and potential treatment strategies.
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Purification Method:
Affinity purification
Gene ID:
120892
Clone Number:
ARC55202
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using LRRK2 Rabbit mAb (CAB22759) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
