The LRRK1 Polyclonal Antibody is a valuable tool for researchers studying LRRK1, a protein kinase involved in various cellular processes including autophagy, inflammation, and cell survival. This antibody, raised in rabbits, is highly specific to human samples and is ideal for use in Western blot applications. By binding to the LRRK1 protein, researchers can effectively analyze and detect its expression in different cell types, making it essential for studies in biology and disease mechanisms.
LRRK1, also known as leucine-rich repeat kinase 1, has been linked to various diseases such as Parkinson's disease, cancer, and inflammatory disorders. Its role in regulating key cellular pathways makes it a promising target for drug development and therapeutic interventions. Understanding the function of LRRK1 is crucial for uncovering its potential as a therapeutic target and advancing research in the field of cell biology and disease pathology.
Product Name:
LRRK1 Polyclonal Antibody
SKU:
CAB21659
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 10-90 of human LRRK1 (NP_078928.3).
This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption.
Purification Method:
Affinity purification
Gene ID:
79705
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells using LRRK1 Rabbit pAb(CAB21659) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
