LRRFIP2 Rabbit Polyclonal Antibody (CAB17046)
- SKU:
- CAB17046
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | LRRFIP2 Rabbit Polyclonal Antibody |
SKU: | CAB17046 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-340 of human LRRFIP2 (NP_060194.1). |
Sequence: | VIEE QEEQ MAEF YREN EEKS KELE RQKH MCSV LQHK MEEL KEGL RQRD ELIE KHGL VIIP DGTP NGDV SHEP VAGA ITVV SQEA AQVL ESAG EGPL DVRL RKLA GEKE ELLS QIRK LKLQ LEEE RQKC SRND GTVG DLAG LQNG SDLQ FIEM QRDA NRQI SEYK FKLS KAEQ DITT LEQS ISRL EGQV LRY |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | HUFI-2; LRRFIP2 |
Positive Sample: | Mouse heart,Mouse skeletal muscle,Rat heart |
Calculated MW: | 82kDa |
Observed MW: | 47kDa |
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.
Purification Method: | Affinity purification |
Gene ID: | 9209 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |