The LRRFIP2 Polyclonal Antibody (CAB17046) is specifically designed for research involving LRRFIP2, a protein that plays a role in regulating immune responses and inflammation. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the LRRFIP2 protein, this antibody enables the detection and analysis of LRRFIP2 in various cell types, making it an ideal tool for studies in immunology and inflammatory diseases.LRRFIP2, also known as Leucine-rich repeat flightless-interacting protein 2, is involved in pathways related to immune signaling and cytokine production.
Its function in modulating immune responses makes it a valuable target for research into diseases such as inflammatory disorders, autoimmune conditions, and cancer. Understanding the role of LRRFIP2 is essential for developing new therapies aimed at modulating immune function and inflammation in various disease states. Overall, the LRRFIP2 Polyclonal Antibody (CAB17046) is a valuable tool for researchers looking to study the function of LRRFIP2 and its implications in immune regulation and inflammatory diseases.
Product Name:
LRRFIP2 Rabbit Polyclonal Antibody
SKU:
CAB17046
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-340 of human LRRFIP2 (NP_060194.1).
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.
Purification Method:
Affinity purification
Gene ID:
9209
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LRRFIP2 Rabbit pAb (CAB17046) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
