| UniProt Protein Function: | LRRC8E: Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore. Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8D), possibly to form a heterohexamerProtein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 19p13.2Cellular Component: integral to membrane; plasma membraneMolecular Function: protein bindingBiological Process: ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q6NSJ5 |
| NCBI GenInfo Identifier: | 392996931 |
| NCBI Gene ID: | 80131 |
| NCBI Accession: | NP_001255213.1 |
| UniProt Secondary Accession: | Q6NSJ5,Q2YDY3, Q7L236, Q8N3B0, Q9H5H8, B3KR78 |
| UniProt Related Accession: | Q6NSJ5 |
| Molecular Weight: | 90,247 Da |
| NCBI Full Name: | volume-regulated anion channel subunit LRRC8E isoform 1 |
| NCBI Synonym Full Names: | leucine-rich repeat containing 8 family member E |
| NCBI Official Symbol: | LRRC8EÂ Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | volume-regulated anion channel subunit LRRC8E |
| UniProt Protein Name: | Volume-regulated anion channel subunit LRRC8E |
| UniProt Synonym Protein Names: | Leucine-rich repeat-containing protein 8E |
| Protein Family: | Volume-regulated anion channel |
| UniProt Gene Name: | LRRC8EÂ Â |
| UniProt Entry Name: | LRC8E_HUMAN |
