The LRRC8E Polyclonal Antibody (PACO36750) is a valuable tool for researchers studying LRRC8E, a critical protein involved in cell volume regulation and cell swelling. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications. By specifically binding to the LRRC8E protein, this antibody enables accurate detection and analysis in a variety of cell types, ideal for investigations in cell biology and cancer research.
LRRC8E, also known as leucine-rich repeat-containing protein 8E, plays a key role in regulating cell volume and maintaining cellular homeostasis. Its involvement in cell swelling processes makes it a promising target for studies on diseases related to cell volume dysregulation, such as cancer and various pathological conditions. Understanding the functions of LRRC8E is crucial for developing therapeutic strategies aimed at modulating cell volume dynamics in disease states.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO36750 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO36750 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human lung tissue using PACO36750 at dilution of 1:100.
Background:
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity).
Synonyms:
Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E), LRRC8E
UniProt Protein Function:
LRRC8E: Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore. Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8D), possibly to form a heterohexamerProtein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 19p13.2Cellular Component: integral to membrane; plasma membraneMolecular Function: protein bindingBiological Process: ion transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
