The LRRC15 Polyclonal Antibody (PAC016631) is a valuable tool for researchers studying LRRC15, a protein associated with immune regulation and cancer development. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the LRRC15 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in immunology and oncology research.LRRC15, also known as leucine-rich repeat-containing protein 15, plays a crucial role in regulating immune responses and has been implicated in the progression of certain cancers.
Understanding the function of LRRC15 is essential for uncovering its potential as a therapeutic target in cancer treatment and immunotherapy. By utilizing the LRRC15 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying immune modulation and tumor development, paving the way for innovative approaches to disease management.
Antibody Name:
LRRC15 Antibody (PACO16631)
Antibody SKU:
PACO16631
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human LRRC15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16631(LRRC15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16631(LRRC15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Leucine-rich repeats (LRRs) are 20-29 amino acid, motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid, protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions. LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma. It is also associated with the pathogenesis of AlzheimerÂ’s disease.
Synonyms:
leucine rich repeat containing 15
UniProt Protein Function:
LRRC15: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3q29Cellular Component: integral to membraneMolecular Function: collagen binding; fibronectin binding; laminin bindingBiological Process: virion attachment, binding of host cell surface receptor; positive regulation of cell migration
leucine-rich repeat-containing protein 15 isoform a
NCBI Synonym Full Names:
leucine rich repeat containing 15
NCBI Official Symbol:
LRRC15Â Â
NCBI Official Synonym Symbols:
LIBÂ Â
NCBI Protein Information:
leucine-rich repeat-containing protein 15; hLib; leucine-rich repeat protein induced by beta amyloid; leucine-rich repeat protein induced by beta-amyloid homolog
UniProt Protein Name:
Leucine-rich repeat-containing protein 15
UniProt Synonym Protein Names:
Leucine-rich repeat protein induced by beta-amyloid homolog; hLib
