The LRRC15 Polyclonal Antibody (PAC016630) is a specialized research tool designed for the study of LRRC15, a cell surface molecule with implications in immune regulation and cancer biology. This antibody, developed through rabbit immunization, boasts high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the LRRC15 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal tool for investigations in immunology and oncology research.LRRC15, also known as a potential immune modulator, plays a crucial role in immune response modulation by regulating inflammation and potentially influencing cancer progression.
Its significance in immune regulation and tumor microenvironment dynamics positions it as a valuable target for research into cancer biology, immunotherapy, and autoimmune diseases. Understanding the functions and mechanisms of LRRC15 is instrumental in the development of novel therapeutic strategies that aim to modulate immune responses and potentially combat cancer and other immune-mediated disorders.
Antibody Name:
LRRC15 Antibody (PACO16630)
Antibody SKU:
PACO16630
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human LRRC15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16630(LRRC15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO16630(LRRC15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Leucine-rich repeats (LRRs) are 20-29 amino acid, motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutations in genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 15 (LRRC15, also designated LIB) is a 581 amino acid, protein that contains 15 LRR repeats and is involved in cell-cell and/or -extracellular matrix interactions. LRRC15 is frequently overexpressed in multiple tumor types, most notably breast carcinoma. It is also associated with the pathogenesis of AlzheimerÂ’s disease.
Synonyms:
leucine rich repeat containing 15
UniProt Protein Function:
LRRC15: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3q29Cellular Component: integral to membraneMolecular Function: collagen binding; fibronectin binding; laminin bindingBiological Process: virion attachment, binding of host cell surface receptor; positive regulation of cell migration
leucine-rich repeat-containing protein 15 isoform a
NCBI Synonym Full Names:
leucine rich repeat containing 15
NCBI Official Symbol:
LRRC15Â Â
NCBI Official Synonym Symbols:
LIBÂ Â
NCBI Protein Information:
leucine-rich repeat-containing protein 15; hLib; leucine-rich repeat protein induced by beta amyloid; leucine-rich repeat protein induced by beta-amyloid homolog
UniProt Protein Name:
Leucine-rich repeat-containing protein 15
UniProt Synonym Protein Names:
Leucine-rich repeat protein induced by beta-amyloid homolog; hLib
