The LRR1 Polyclonal Antibody (PAC046866) is a valuable tool for researchers studying the LRR1 protein, which plays essential roles in cellular processes such as protein trafficking and autophagy. The antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in Western blot and immunofluorescence applications.LRR1 is a key component of the ERAD (ER-associated degradation) pathway, where it assists in the degradation of misfolded proteins in the endoplasmic reticulum.
Dysregulation of this pathway can lead to the accumulation of toxic protein aggregates, contributing to the development of neurodegenerative diseases and other proteinopathies.By targeting the LRR1 protein, researchers can gain insights into the mechanisms underlying protein quality control and cellular stress responses. This antibody offers a reliable tool for investigating LRR1 function in various cellular contexts, making it an indispensable resource for studies in cell biology and disease mechanisms.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO46866 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46866 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO46866 at dilution of 1:100.
Background:
May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Synonyms:
Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5), LRR1, PPIL5
UniProt Protein Function:
PPIL5: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 14q21.3Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
