The LRR1 Polyclonal Antibody (PAC011405) is a valuable tool for researchers studying LRR1, a protein involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the LRR1 protein, this antibody enables accurate detection and analysis in different cell types, making it ideal for investigations in molecular biology and cell signaling pathways.LRR1, or Leucine Rich Repeat Protein 1, is known for its role in protein-protein interactions and its involvement in cellular processes such as autophagy and protein degradation.
Its functions in these pathways make it a key target for research in fields such as cancer biology, neurodegenerative diseases, and autophagy-related disorders. By understanding the mechanisms and functions of LRR1, researchers can gain insights into disease mechanisms and potentially develop targeted therapies for various conditions.
PPIL5: May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 14q21.3Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
