The LRP8 Polyclonal Antibody (CAB10517) is a powerful tool for researchers studying LRP8, a cell surface receptor involved in various cellular processes, including lipid metabolism, neuronal development, and cellular signaling. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the LRP8 protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it ideal for research in neurobiology, cardiovascular disease, and lipid metabolism.
LRP8, also known as apolipoprotein E receptor 2, plays a crucial role in regulating cellular cholesterol levels and modulating synaptic plasticity in the brain. Its involvement in lipid metabolism and neuronal development suggests its potential significance in neurological disorders, cardiovascular disease, and neurodegenerative conditions. By investigating the function of LRP8, researchers can gain valuable insights into these disease pathways and potentially uncover new therapeutic targets for treatment.
Product Name:
ApoER2/LRP8 Rabbit Polyclonal Antibody
SKU:
CAB10517
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 900 to the C-terminus of human ApoER2/ApoER2/LRP8 (NP_004622.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
106kDa
Observed MW:
105-120kDa
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
7804
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ApoER2/ApoER2/LRP8 antibody (CAB10517) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
