LRP6 Rabbit Polyclonal Antibody (CAB15070)
- SKU:
- CAB15070
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | LRP6 Rabbit Polyclonal Antibody |
SKU: | CAB15070 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human LRP6 (NP_002327.2). |
Sequence: | APLL LYAN RRDL RLVD ATNG KENA TIVV GGLE DAAA VDFV FSHG LIYW SDVS EEAI KRTE FNKT ESVQ NVVV SGLL SPDG LACD WLGE KLYW TDSE TNRI EVSN LDGS LRKV LFWQ ELDQ PRAI ALDP SSG |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | ADCAD2; STHAG7; LRP6 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum, Membrane, Single-pass type I membrane protein. |
Calculated MW: | 180kDa |
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Purification Method: | Affinity purification |
Gene ID: | 4040 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |