LRP6 Monoclonal Antibody (CAB22661)
- SKU:
- CAB22661
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | LRP6 Monoclonal Antibody |
SKU: | CAB22661 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human LRP6 (NP_002327.2). |
Sequence: | CSHL CLAV PVGG FVCG CPAH YSLN ADNR TCSA PTTF LLFS QKSA INRM VIDE QQSP DIIL PIHS LRNV RAID YDPL DKQL YWID SRQN MIRK AQED GSQG F |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | ADCAD2; STHAG7; LRP6 |
Positive Sample: | HeLa,Mouse lung,Rat colon |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum, Membrane, Single-pass type I membrane protein. |
Calculated MW: | 180kDa |
Observed MW: | 180kDa |
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Purification Method: | Affinity purification |
Gene ID: | 4040 |
Clone Number: | ARC54062 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |