The LRP5 Polyclonal Antibody (CAB0130) is a valuable tool for researchers studying the LRP5 protein, which plays a crucial role in the Wnt signaling pathway. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.LRP5 is a membrane receptor involved in cell signaling pathways that regulate cell proliferation, differentiation, and survival. Dysregulation of the Wnt pathway, in which LRP5 is a key player, has been implicated in various diseases including cancer, osteoporosis, and neurological disorders.
By using the LRP5 Polyclonal Antibody, researchers can detect and analyze LRP5 protein expression in various cell types, providing valuable insights into its function and potential therapeutic targets for diseases associated with Wnt pathway dysregulation.Overall, the LRP5 Polyclonal Antibody is a powerful tool for investigating the role of LRP5 in cellular processes and disease development, making it an essential component of research in molecular biology, cancer biology, and drug discovery.
Product Name:
LRP5 Rabbit Polyclonal Antibody
SKU:
CAB0130
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human LRP5 (NP_002326.2).
Endoplasmic reticulum, Membrane, Single-pass type I membrane protein.
Calculated MW:
179kDa
Observed MW:
180-200kDa
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4041
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LRP5 antibody (CAB0130) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
