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LRP5 Monoclonal Antibody (CAB22327)

SKU:
CAB22327
€139
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Description

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Product Name:LRP5 Monoclonal Antibody
SKU:CAB22327
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human LRP5 (NP_002326.2).
Sequence:MGGV YFVC QRVV CQRY AGAN GPFP HEYV SGTP HVPL NFIA PGGS QHGP FTGI ACGK SMMS SVSL MGGR GGVP LYDR NHVT GASS SSSS STKA TLYP PILN P
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; LRP-7; OPTA1; PCLD4; VBCH2; LRP5
Positive Sample:HCT116,SW620,Mouse spleen,Mouse lung
Conjugate:Unconjugated
Cellular Localization:endoplasmic reticulum, plasma membrane
Calculated MW:179kDa
Observed MW:200kDa

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:4041
Clone Number:ARC52451
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using LRP5 Rabbit mAb (CAB22327) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.

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