The LRP5 Monoclonal Antibody (CAB22327) is a valuable tool for researchers studying the Low-density lipoprotein receptor-related protein 5 (LRP5), a cell surface receptor involved in various cellular processes, including Wnt signaling and lipid metabolism. This monoclonal antibody, produced using hybridoma technology, specifically targets the LRP5 protein in human samples and is validated for use in applications such as Western blot and immunohistochemistry.LRP5 plays a crucial role in bone formation and development, making it a potential target for therapeutic interventions in conditions such as osteoporosis and bone disorders.
Additionally, aberrant LRP5 signaling has been implicated in cancer progression and cardiovascular diseases, highlighting the importance of studying this receptor in biomedical research.By utilizing the LRP5 Monoclonal Antibody, researchers can effectively investigate the role of LRP5 in various physiological and pathological processes, providing valuable insights for the development of novel therapies and treatment strategies. Its high specificity and sensitivity make it a reliable tool for studies in cell biology, molecular biology, and drug discovery related to LRP5 function and regulation.
Product Name:
LRP5 Monoclonal Antibody
SKU:
CAB22327
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human LRP5 (NP_002326.2).
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4041
Clone Number:
ARC52451
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using LRP5 Rabbit mAb (CAB22327) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
