The LRP3 Polyclonal Antibody (PAC018175) is a powerful tool for researchers studying LRP3, a cell surface protein involved in various cellular processes, including lipid metabolism, inflammation, and immune response regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting LRP3 in human samples, making it reliable for use in Western blotting and immunofluorescence experiments.LRP3, also known as low-density lipoprotein receptor-related protein 3, is a key player in lipid homeostasis and inflammatory signaling pathways. Its role in modulating immune responses suggests its potential as a therapeutic target for conditions such as atherosclerosis, obesity, and autoimmune diseases.
Research on LRP3 could unveil new insights into the underlying mechanisms of these disorders, paving the way for the development of novel treatments targeting this protein.Overall, the LRP3 Polyclonal Antibody is a valuable tool for researchers investigating the functions and implications of LRP3 in various physiological and pathological conditions, offering a deeper understanding of its role in health and disease.
Antibody Name:
LRP3 Antibody (PACO18175)
Antibody SKU:
PACO18175
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human LRP3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18175(LRP3 Antibody) at dilution 1/80, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Low density lipoprotein receptor-related protein 3 (LRP-3) is a protein that in humans is encoded by theLRP3 gene. Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
Synonyms:
low density lipoprotein receptor-related protein 3
UniProt Protein Function:
LRP3: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro. Belongs to the LDLR family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 19q13.11Biological Process: receptor-mediated endocytosis
