LRP2 Rabbit Polyclonal Antibody (CAB3612)
- SKU:
- CAB3612
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | LRP2 Rabbit Polyclonal Antibody |
SKU: | CAB3612 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human LRP2 (NP_004516.2). |
Sequence: | FHYR RTGS LLPA LPKL PSLS SLVK PSEN GNGV TFRS GADL NMDI GVSG FGPE TAID RSMA MSED FVME MGKQ PIIF ENPM YSAR DSAV KVVQ PIQV TVSE NVDN KNYG SPIN PSEI VPET NPTS PAAD GTQV TKWN LFKR KSKQ TTNF ENPI YAQM ENEQ KESV AATP PPSP SLPA KPKP PSRR DPTP TYSA TEDT FKDT ANLV KEDS EV |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 IHC-P,1:20 - 1:100 |
Synonyms: | DBS; GP330; LRP-2; LRP2 |
Positive Sample: | Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein, coated pit. |
Calculated MW: | 522kDa |
Observed MW: | 522kDa |
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
Purification Method: | Affinity purification |
Gene ID: | 4036 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |