The LRP1 Rabbit Monoclonal Antibody is specifically designed for research involving LRP1, a cell surface receptor involved in various cellular processes, including lipid metabolism, signaling, and clearance of extracellular molecules. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. It binds to the LRP1 protein, enabling accurate detection and analysis in a variety of cell types, making it an essential tool for studies in cardiovascular disease, neurodegenerative disorders, and cancer research.
LRP1, also known as low-density lipoprotein receptor-related protein 1, is a multifunctional receptor that plays a key role in regulating cholesterol metabolism, cell signaling pathways, and cellular uptake of various ligands. Its involvement in these processes makes it an attractive target for investigating diseases such as atherosclerosis, Alzheimer's disease, and various types of cancer. Understanding the function of LRP1 is crucial for developing targeted therapies and interventions that can modulate its activity for therapeutic purposes.
Product Name:
LRP1 Rabbit Monoclonal Antibody
SKU:
CAB0633
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 4400-4500 of human LRP1 (Q07954).
Cell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit.
Calculated MW:
505kDa
Observed MW:
85kDa
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Purification Method:
Affinity purification
Gene ID:
4035
Clone Number:
ARC0275
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using LRP1 Rabbit mAb (CAB0633) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
