LRP1 Rabbit Monoclonal Antibody (CAB0633)
- SKU:
- CAB0633
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | LRP1 Rabbit Monoclonal Antibody |
SKU: | CAB0633 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 4400-4500 of human LRP1 (Q07954). |
Sequence: | PPHM TGPR CEEH VFSQ QQPG HIAS ILIP LLLL LLLV LVAG VVFW YKRR VQGA KGFQ HQRM TNGA MNVE IGNP TYKM YEGG EPDD VGGL LDAD FALD PDKP T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1; LRP1 |
Positive Sample: | U-87MG,Mouse lung,Mouse liver,Mouse brain,Rat lung,Rat liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit. |
Calculated MW: | 505kDa |
Observed MW: | 85kDa |
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Purification Method: | Affinity purification |
Gene ID: | 4035 |
Clone Number: | ARC0275 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |