The LRP1 Polyclonal Antibody (CAB1439) is a specialized tool for scientists studying the Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1). This antibody, produced in rabbits, is highly specific to human LRP1 protein and has been validated for use in Western blot applications.LRP1 is a multifunctional cell surface receptor involved in various biological processes, including lipid metabolism, cellular signaling, and clearance of molecules from the extracellular space. Dysregulation of LRP1 has been implicated in a wide range of diseases, such as Alzheimer's disease, atherosclerosis, and cancer.
By using the LRP1 Polyclonal Antibody, researchers can accurately detect and analyze LRP1 protein levels in different cell types, providing valuable insights into its role in health and disease. This antibody is an essential tool for studies in molecular biology, cardiovascular research, and neurodegenerative diseases, helping to advance our understanding of LRP1 function and its potential as a therapeutic target.
Product Name:
LRP1 Rabbit Polyclonal Antibody
SKU:
CAB1439
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 4401-4500 of LRP1 (NP_002323.2).
Cell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit.
Calculated MW:
505kDa
Observed MW:
505kDa
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Purification Method:
Affinity purification
Gene ID:
4035
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using LRP1 Rabbit pAb (CAB1439) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
