The LRP1 Polyclonal Antibody (CAB13509) is a valuable tool for researchers studying the Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1), a multifunctional cell surface receptor involved in various physiological processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding to the LRP1 protein, this antibody enables precise detection and analysis in a range of cell types, making it an excellent choice for studies in cardiovascular disease, Alzheimer's disease, and other conditions where LRP1 plays a crucial role.
LRP1, also known as CD91, is a key player in lipid metabolism, cellular signaling, and clearance of extracellular ligands. Dysregulation of LRP1 has been implicated in the pathogenesis of atherosclerosis, Alzheimer's disease, and other disorders. By understanding the mechanisms of LRP1 function, researchers can gain insights into potential therapeutic targets for these conditions. The LRP1 Polyclonal Antibody is a valuable tool for advancing research in this field and uncovering new avenues for treatment and prevention strategies.
Product Name:
LRP1 Rabbit Polyclonal Antibody
SKU:
CAB13509
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-168 of LRP1 (NP_002323.2).
Cell membrane, Cytoplasm, Extracellular side, Membrane, Nucleus, Peripheral membrane protein, Single-pass type I membrane protein, coated pit.
Calculated MW:
505kDa
Observed MW:
85kDa
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Purification Method:
Affinity purification
Gene ID:
4035
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LRP1 Rabbit pAb (CAB13509) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
