The LRIG3 Polyclonal Antibody (PAC061406) is a vital tool for researchers studying LRIG3, a transmembrane protein involved in the regulation of growth factor signaling pathways. This antibody, derived from rabbits, exhibits high specificity for human samples and has been validated for use in a variety of applications including Western blot and immunohistochemistry.LRIG3, a member of the LRIG family of proteins, has been shown to modulate the activity of receptor tyrosine kinases like EGFR and MET, highlighting its importance in cell growth and proliferation processes. By targeting LRIG3 with this antibody, researchers can detect and analyze the expression of LRIG3 in different cell types, providing valuable insights into its functions in normal physiology and disease states.
The role of LRIG3 in cancer development and progression has garnered significant interest, as dysregulation of growth factor signaling pathways is often implicated in tumorigenesis. Further understanding of LRIG3's mechanisms of action may lead to the identification of novel therapeutic targets for cancer treatment. In addition, this antibody may also be instrumental in investigating the potential role of LRIG3 in other diseases related to aberrant growth factor signaling, offering new possibilities for therapeutic interventions.
Antibody Name:
LRIG3 Antibody (PACO61406)
Antibody SKU:
PACO61406
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Leucine-rich repeats and immunoglobulin-like domains protein 3 protein (835-985AA)
Immunofluorescence staining of U251 cells with PACO61406 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).
Synonyms:
Leucine-rich repeats and immunoglobulin-like domains protein 3, LIG-3, LRIG3, LIG3, UNQ287/PRO326/PRO335
UniProt Protein Function:
LRIG3: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12q14.1Cellular Component: extracellular space
