The LRIG3 Antibody (PAC018165) is a polyclonal antibody designed for research involving LRIG3, a cell surface molecule known for its role in regulating cell proliferation and growth. The antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in various applications including Western blotting.LRIG3 is a member of the LRIG (leucine-rich repeats and immunoglobulin-like domains) family of proteins, which have been implicated in several cellular processes including cell signaling, adhesion, and differentiation.
LRIG3 specifically has been shown to inhibit the growth of cancer cells and regulate the activity of receptor tyrosine kinases, making it a potential target for cancer therapy research.The LRIG3 Antibody enables the detection and analysis of LRIG3 protein expression in a variety of cell types, making it an invaluable tool for studies in oncology, cell biology, and drug development. Understanding the function and regulation of LRIG3 may provide important insights into cancer biology and potential therapeutic strategies targeting this protein.
Antibody Name:
LRIG3 Antibody (PACO18165)
Antibody SKU:
PACO18165
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human LRIG3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18165(LRIG3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Leucine-rich repeats and immunoglobulin-like domains 3 (Lrig3) was identified by microarray analysis among genes that show differential expression during gastrulation in Xenopus laevis. Lrig3 was expressed in the neural plate and neural crest (NC) at neurula stages, and in NC derivatives and other dorsal structures during tailbud stages. A prominent consequence of the morpholino-induced inhibition of Lrig3 expression was impaired NC formation, as revealed by the suppression of marker genes, including Slug, Sox9 and Foxd3.
Synonyms:
leucine-rich repeats and immunoglobulin-like domains 3
UniProt Protein Function:
LRIG3: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12q14.1Cellular Component: extracellular space
