The LRCH1 Polyclonal Antibody (PAC047266) is a valuable tool for researchers studying LRCH1, a protein involved in cell signaling and potentially linked to cancer development. This antibody, produced in rabbits, is highly specific to LRCH1 in human samples and has been validated for use in Western blotting applications. By targeting LRCH1, researchers can investigate its role in signaling pathways and its potential impact on cancer progression.LRCH1, also known as leucine-rich repeats and calponin homology domain containing protein 1, is thought to play a role in cell adhesion, migration, and cytoskeletal organization.
Its overexpression has been associated with certain types of cancer, making it a promising target for therapeutic intervention. The LRCH1 Polyclonal Antibody allows for the detection and analysis of LRCH1 in various cell types, providing insights into its function and potential as a therapeutic target in cancer research.
Western blot. All lanes: LRCH1 antibody at 15µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 81, 78, 85 kDa. Observed band size: 81 kDa..
Immunofluorescent analysis of MCF-7 cells using PACO47266 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO47266 at dilution of 1:100.
Synonyms:
Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81), LRCH1, CHDC1 KIAA1016
UniProt Protein Function:
LRCH1: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q14.11
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]
