The LRBA Antibody (PAC028013) is an essential tool for researchers studying LRBA, a protein involved in immune regulation and maintaining immune homeostasis. This polyclonal antibody, produced in rabbits, is highly specific to human LRBA samples and is validated for use in Western blot applications. By binding to LRBA, this antibody enables the detection and analysis of LRBA in various cell types, making it a valuable asset for studies in immunology and autoimmune diseases.LRBA, also known as lipopolysaccharide-responsive beige-like anchor protein, plays a crucial role in modulating immune responses by regulating T-cell activation and cytokine production. Dysregulation of LRBA has been linked to autoimmune disorders, particularly in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome.
Research into LRBA function is vital for understanding the underlying mechanisms of immune-related diseases and developing potential therapeutic interventions.By utilizing the LRBA Antibody (PAC028013), researchers can gain insights into the role of LRBA in immune regulation and its potential implications in autoimmune diseases and other immune-related disorders. This antibody serves as a valuable tool for elucidating the molecular pathways involving LRBA and advancing our knowledge of immune system function.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO28013 at dilution of 1:20.
Immunofluorescent analysis of MCF-7 cells using PACO28013 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescent analysis of U251 cells using PACO28013 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules
Synonyms:
Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein), LRBA, BGL CDC4L LBA
UniProt Protein Function:
May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
