The LPL Polyclonal Antibody (CAB16252) is a powerful tool for researchers studying lipoprotein lipase (LPL), an enzyme crucial for lipid metabolism. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting LPL in human samples, making it a reliable choice for Western blot applications.Lipoprotein lipase plays a key role in breaking down triglycerides found in circulating lipoproteins, making it a key player in regulating plasma lipid levels. Dysregulation of LPL activity has been linked to metabolic disorders such as hypertriglyceridemia and cardiovascular disease, making it a promising target for therapeutic interventions.
By using the LPL Polyclonal Antibody, researchers can investigate the expression and function of LPL in various cell types and tissues, providing valuable insights into lipid metabolism and its implications in metabolic diseases. This antibody is a valuable tool for studies in the fields of metabolism, cardiovascular health, and obesity research.
Recombinant fusion protein containing a sequence corresponding to amino acids 124-475 of human Lipoprotein lipase (Lipoprotein lipase (LPL)) (NP_000228.1).
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
Purification Method:
Affinity purification
Gene ID:
4023
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Lipoprotein lipase (LPL) antibody (CAB16252) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
