The LPIN1 Polyclonal Antibody (CAB8486) is a valuable tool for researchers studying LPIN1, a key protein involved in various cellular processes including lipid metabolism and inflammation regulation. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the LPIN1 protein, this antibody allows for the detection and analysis of LPIN1 in a variety of cell types, making it ideal for research in the fields of metabolism, inflammation, and lipid biology.LPIN1 is a crucial player in lipid metabolism, serving as a transcriptional coactivator involved in the regulation of genes that control lipid synthesis and storage.
It also plays a role in inflammation by regulating the production of inflammatory molecules. Understanding the function and regulation of LPIN1 is essential for unraveling its role in metabolic disorders, inflammatory diseases, and even certain types of cancer. The LPIN1 Polyclonal Antibody provides researchers with a powerful tool to investigate the implications of LPIN1 dysregulation in various pathological conditions and may lead to the development of new therapeutic strategies targeting LPIN1.
Product Name:
Lipin 1 Rabbit Polyclonal Antibody
SKU:
CAB8486
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 261-414 of human Lipin 1 (NP_663731.1).
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes.
Purification Method:
Affinity purification
Gene ID:
23175
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of rat skeletal muscle, using Lipin 1 antibody (CAB8486) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
