The LPIN1 Polyclonal Antibody (CAB14111) is a valuable tool for researchers studying LPIN1, a key protein involved in lipid metabolism and cellular homeostasis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is optimized for use in Western blot applications. By binding specifically to the LPIN1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for research in metabolism, obesity, and related disorders.
LPIN1, also known as lipin-1, plays a critical role in lipid synthesis, storage, and signaling processes within cells. Its functions are vital for maintaining metabolic balance and energy regulation, making it a target of interest in studies on obesity, diabetes, and metabolic syndrome. By understanding the role of LPIN1 in these conditions, researchers can develop targeted therapies and interventions to address metabolic disorders and associated health risks.
Product Name:
Lipin 1 Polyclonal Antibody
SKU:
CAB14111
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 261-414 of human Lipin 1 (NP_663731.1).
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes.
Purification Method:
Affinity purification
Gene ID:
23175
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Lipin 1 Rabbit pAb (CAB14111) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
