The LPHN3 Polyclonal Antibody (PACO10282) is a valuable tool for researchers studying the role of LPHN3, a cell surface receptor implicated in various physiological processes, particularly in the central nervous system. The antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in applications such as Western blotting.LPHN3, also known as latrophilin 3, is known to play a crucial role in neuronal development, synaptic transmission, and neurodevelopmental disorders. Its involvement in these processes makes it a promising target for research into conditions such as autism, schizophrenia, and ADHD.
By using the LPHN3 antibody, researchers can detect and analyze the expression of this receptor in different cell types, providing valuable insights into its function and potential therapeutic implications.Overall, the LPHN3 Polyclonal Antibody (PACO10282) is a reliable tool for studying the biology of LPHN3 and its implications in neurobiology and related disorders. Its high reactivity and specificity make it ideal for use in research settings focused on understanding the role of this receptor in health and disease.
latrophilin 3: a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]Protein type: Membrane protein, integral; GPCR, family 2; Receptor, GPCR; Membrane protein, multi-passChromosomal Location of Human Ortholog: 4q13.1Cellular Component: axon; integral to plasma membrane; intercellular junctionMolecular Function: calcium ion binding; protein bindingBiological Process: neuron migration; synaptogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
