UniProt Protein Function: | Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (). |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] |
UniProt Code: | O94910 |
NCBI GenInfo Identifier: | 57165355 |
NCBI Gene ID: | 22859 |
NCBI Accession: | NP_001008701.1 |
UniProt Secondary Accession: | O94910,Q96IE7, Q9BU07, Q9HAR3 |
UniProt Related Accession: | O94910 |
Molecular Weight: | 162,118 Da |
NCBI Full Name: | adhesion G protein-coupled receptor L1 isoform 1 |
NCBI Synonym Full Names: | adhesion G protein-coupled receptor L1 |
NCBI Official Symbol: | ADGRL1Â Â |
NCBI Official Synonym Symbols: | CL1; LEC2; CIRL1; LPHN1Â Â |
NCBI Protein Information: | adhesion G protein-coupled receptor L1 |
UniProt Protein Name: | Adhesion G protein-coupled receptor L1 |
UniProt Synonym Protein Names: | Calcium-independent alpha-latrotoxin receptor 1 |
Protein Family: | |
UniProt Gene Name: | ADGRL1Â Â |
UniProt Entry Name: | |