The LPHN1 Polyclonal Antibody (PACO03669) is a valuable tool for researchers investigating LPHN1, a cell surface protein involved in neuronal development and neurotransmitter release. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the LPHN1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in neuroscience and neurobiology.
LPHN1, also known as Latrophilin-1, is a key player in synaptic transmission and neuronal communication, making it essential for proper brain function. Research on LPHN1 has implications for understanding neurological disorders such as ADHD, autism, and schizophrenia, as well as potential therapeutic targets for these conditions. By investigating the role of LPHN1, researchers can gain insight into underlying mechanisms of neurological diseases and potential treatments.
Antibody Name:
LPHN1 Antibody
Antibody SKU:
PACO03669
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Latrophilin-1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
