The LPGAT1 Polyclonal Antibody (PACO38090) is a valuable tool for researchers studying LPGAT1, a key enzyme involved in phospholipid metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the LPGAT1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for investigations in lipid metabolism and related pathways.LPGAT1, also known as lysophosphatidylglycerol acyltransferase 1, plays a crucial role in the synthesis of phosphatidylglycerol, a major component of biological membranes.
By understanding the function and regulation of LPGAT1, researchers can gain insights into lipid biology and its implications for diseases such as metabolic disorders and cardiovascular conditions. The LPGAT1 Polyclonal Antibody is an invaluable tool for exploring the role of this enzyme in cellular processes and disease mechanisms.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO38090 at dilution of 1:100.
Western Blot. Positive WB detected in: HEK293 whole cell lysate, Hela whole cell lysate. All lanes: LPGAT1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44 kDa. Observed band size: 44 kDa.
Background:
Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.
LPGAT1: Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Protein type: EC 2.3.1.-; Membrane protein, multi-pass; Transferase; Membrane protein, integralChromosomal Location of Human Ortholog: 1q32Cellular Component: cytoplasm; endoplasmic reticulum membrane; membraneMolecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
