| UniProt Protein Function: | P2RY5: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Defects in LPAR6 are the cause of woolly hair autosomal recessive type 1 with or without hypotrichosis (ARWH1). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Defects in LPAR6 are the cause of hypotrichosis type 8 (HYPT8). A condition characterized by the presence of less than the normal amount of hair. Affected individuals show progressive hair loss, thinning of scalp hair since early childhood, sparse body hair, and sparse eyebrows and eyelashes in some cases. Belongs to the G-protein coupled receptor 1 family.Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-passChromosomal Location of Human Ortholog: 13q14Cellular Component: plasma membrane; integral to membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathwayDisease: Hypotrichosis 8 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] |
| UniProt Code: | P43657 |
| NCBI GenInfo Identifier: | 241982708 |
| NCBI Gene ID: | 10161 |
| NCBI Accession: | NP_001155970.1 |
| UniProt Secondary Accession: | P43657,O15133, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6 A4FTW9, B3KVF2 |
| UniProt Related Accession: | P43657 |
| Molecular Weight: | 39,392 Da |
| NCBI Full Name: | lysophosphatidic acid receptor 6 |
| NCBI Synonym Full Names: | lysophosphatidic acid receptor 6 |
| NCBI Official Symbol: | LPAR6Â Â |
| NCBI Official Synonym Symbols: | LAH3; P2Y5; ARWH1; P2RY5Â Â |
| NCBI Protein Information: | lysophosphatidic acid receptor 6; LPA-6; LPA receptor 6; P2Y purinoceptor 5; purinergic receptor 5; G-protein coupled purinergic receptor P2Y5; RB intron encoded G-protein coupled receptor; oleoyl-L-alpha-lysophosphatidic acid receptor; purinergic recepto |
| UniProt Protein Name: | Lysophosphatidic acid receptor 6 |
| UniProt Synonym Protein Names: | Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor |
| Protein Family: | Lysophosphatidic acid receptor |
| UniProt Gene Name: | LPAR6Â Â |
| UniProt Entry Name: | LPAR6_HUMAN |
