The LPAR5 Polyclonal Antibody (PACO00881) is a valuable tool for researchers studying Lysophosphatidic Acid Receptor 5 (LPAR5), a G protein-coupled receptor involved in various cellular processes, including cell migration, proliferation, and survival. This polyclonal antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the LPAR5 protein, this antibody enables accurate detection and analysis in a range of cell types, making it ideal for studies in cell biology, signal transduction, and drug development.
LPAR5 is known to play a crucial role in mediating cellular responses to lysophosphatidic acid (LPA), a bioactive lipid with diverse physiological functions. Dysregulation of LPAR5 signaling has been implicated in various diseases, including cancer, fibrosis, and neurological disorders, making it an attractive target for therapeutic intervention. By investigating the function and expression of LPAR5 using this polyclonal antibody, researchers can gain valuable insights into the mechanisms underlying these pathologies and explore new avenues for targeted treatment strategies.
Antibody Name:
LPAR5 Antibody
Antibody SKU:
PACO00881
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human GPR92.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GPR92: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1Chromosomal Location of Human Ortholog: 12p13.31Cellular Component: integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
