The LPAR2 Polyclonal Antibody (CAB14819) is specifically designed for research involving Lysophosphatidic Acid Receptor 2 (LPAR2), a G protein-coupled receptor that plays a key role in various physiological processes, including cell proliferation, migration, and survival. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for studying LPAR2 expression and function in cell biology and pharmacology research.LPAR2, a member of the lysophospholipid receptor family, is involved in signal transduction pathways that regulate cell growth and survival. Its activation by lysophosphatidic acid (LPA) leads to downstream signaling events that can impact cellular processes such as cell adhesion, cytoskeletal rearrangement, and gene expression.
Research on LPAR2 is essential for understanding its role in health and disease, particularly in cancer, neurodegenerative disorders, and cardiovascular conditions.By using the LPAR2 Polyclonal Antibody (CAB14819) in techniques like Western blotting and immunofluorescence, researchers can investigate the expression levels and localization of LPAR2 in different cell types and tissues. This antibody provides a valuable tool for studying the molecular mechanisms underlying LPAR2 signaling pathways and exploring its potential as a therapeutic target in various pathological conditions.
Product Name:
LPAR2 Rabbit Polyclonal Antibody
SKU:
CAB14819
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human LPAR2 (NP_004711.2).
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.
Purification Method:
Affinity purification
Gene ID:
9170
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HL-60 cells, using LPAR2 Rabbit pAb (CAB14819) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
