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LPA Antibody (PACO34866)

SKU:
PACO34866
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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LPA Antibody (PACO34866)

The LPA Antibody (PAC034866) is a highly specific polyclonal antibody designed for research involving LPA, a bioactive lipid molecule known for its role in numerous cellular processes. This antibody, produced in rabbits, shows strong reactivity with human samples and has been validated for use in Western blot applications. By binding to LPA, this antibody allows for the detection and analysis of LPA levels in various cell types, making it ideal for studies in lipid signaling pathways, cell migration, and cancer research.LPA, or lysophosphatidic acid, is a potent signaling molecule that is involved in a wide range of biological functions, including cell proliferation, survival, and migration.

Dysregulation of LPA signaling has been implicated in various diseases such as cancer, fibrosis, and neurodegenerative disorders. As such, understanding the mechanisms underlying LPA signaling and its effects on cellular processes is crucial for developing targeted therapies for these conditions.Overall, the PAC034866 LPA Antibody is a valuable tool for researchers investigating the role of LPA in health and disease. Its high specificity and reactivity make it a reliable choice for studying the complex functions of this bioactive lipid molecule in various cellular contexts.

Antibody Name:LPA Antibody (PACO34866)
Antibody SKU:PACO34866
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Apolipoprotein(a) protein (3999-4112AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
Synonyms:Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-), LPA
UniProt Protein Function:LPA: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. Belongs to the peptidase S1 family. Plasminogen subfamily.
UniProt Protein Details:

Protein type:Inhibitor; Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: extracellular region

Molecular Function:heparin binding; protein binding; serine-type endopeptidase activity; fibronectin binding; endopeptidase inhibitor activity; apolipoprotein binding

Biological Process: receptor-mediated endocytosis; blood circulation; lipoprotein metabolic process; lipid metabolic process; lipid transport; proteolysis

NCBI Summary:The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
UniProt Code:P08519
NCBI GenInfo Identifier:114062
NCBI Gene ID:4018
NCBI Accession:P08519.1
UniProt Secondary Accession:P08519,Q5VTD7, Q9UD88,
UniProt Related Accession:P08519
Molecular Weight:280,000-700,000
NCBI Full Name:Apolipoprotein(a)
NCBI Synonym Full Names:lipoprotein, Lp(a)
NCBI Official Symbol:LPA  
NCBI Official Synonym Symbols:LP; AK38; APOA  
NCBI Protein Information:apolipoprotein(a)
UniProt Protein Name:Apolipoprotein(a)
Protein Family:Late promoter-activating protein
UniProt Gene Name:LPA  
UniProt Entry Name:APOA_HUMAN

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