LOXL3 Antibody (PACO28001)
- SKU:
- PACO28001
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
LOXL3 Antibody (PACO28001)
The LOXL3 Antibody (PAC028001) is a valuable tool for researchers studying lysyl oxidase-like 3 (LOXL3), an enzyme involved in extracellular matrix remodeling and tissue homeostasis. This polyclonal antibody, raised in rabbits, is highly specific to LOXL3 and is validated for use in various applications, including Western blot and immunohistochemistry.LOXL3 plays a critical role in the crosslinking of collagen and elastin fibers, contributing to the structural integrity of tissues such as skin, blood vessels, and lungs. Dysregulation of LOXL3 expression has been linked to a variety of diseases, including fibrosis, cancer, and cardiovascular disorders.
By using the LOXL3 Antibody, researchers can investigate the expression levels and localization of LOXL3 in different cell types and tissues, providing valuable insights into its function and potential therapeutic implications.Overall, the LOXL3 Antibody is a powerful tool for advancing research in areas such as tissue remodeling, fibrosis, and cancer biology. Its high sensitivity and specificity make it a reliable choice for scientists seeking to understand the role of LOXL3 in health and disease.
| Antibody Name: | LOXL3 Antibody (PACO28001) |
| Antibody SKU: | PACO28001 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Lysyl oxidase homolog 3 protein (401-608AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO28001 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO28001 at dilution of 1:100. |
| Background: | Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV. |
| Synonyms: | Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3), LOXL3, LOXL |
| UniProt Protein Function: | LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted; EC 1.4.3.-; Secreted, signal peptide; Oxidoreductase Chromosomal Location of Human Ortholog: 2p13 Cellular Component: extracellular region; nucleus Molecular Function:protein binding Biological Process: epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P58215 |
| NCBI GenInfo Identifier: | 14916616 |
| NCBI Gene ID: | 84695 |
| NCBI Accession: | P58215.1 |
| UniProt Secondary Accession: | P58215,Q2EHP2, Q6IPL7, Q96RS1, D6W5J1, |
| UniProt Related Accession: | P58215 |
| Molecular Weight: | 67,445 Da |
| NCBI Full Name: | Lysyl oxidase homolog 3 |
| NCBI Synonym Full Names: | lysyl oxidase like 3 |
| NCBI Official Symbol: | LOXL3Â Â |
| NCBI Official Synonym Symbols: | LOXLÂ Â |
| NCBI Protein Information: | lysyl oxidase homolog 3 |
| UniProt Protein Name: | Lysyl oxidase homolog 3 |
| UniProt Synonym Protein Names: | Lysyl oxidase-like protein 3 |
| Protein Family: | Lysyl oxidase |
| UniProt Gene Name: | LOXL3Â Â |
| UniProt Entry Name: | LOXL3_HUMAN |
| ELISA Kits |
| Human LOXL3 / Lysyl Oxidase Homolog 3 ELISA Kit |
| Human Lysyl oxidase homolog 3 (LOXL3) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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Human LOXL3 / Lysyl Oxidase Homolog 3 ELISA Kit
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Human Lysyl Oxidase Like Protein 3 (LOXL3) ELISA Kit
